Engineered pH-sensitive protein switches

Case ID:

C12712

Here we show that a single charge buried in a hydrophobic environment in a protein can stabilize a partially folded protein. This suggests a strategy that will greatly facilitate the study of structural and thermodynamic properties of protein folding intermediates, and also suggests how buried ionizable groups can be used to engineer artificial pH sensing domains in proteins.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
Insertion of Charge in the Hydrophobic Interior of Proteins as a Strategy for Engineering pH-sensitive Switches	ORD: Ordinary Utility	United States	14/507,381	10,138,471	10/6/2014	11/27/2018	3/3/2036	Granted
Insertion of Charge in the Hydrophobic Interior of Proteins as a Strategy for Engineering pH-sensitive Switches	PCT: Patent Cooperation Treaty	European Patent Office	14851059.7		10/6/2014			Abandoned
Insertion of Charge in the Hydrophobic Interior of Proteins as a Strategy for Engineering pH-sensitive Switches	PCT: Patent Cooperation Treaty	Canada	2,926,248		10/6/2014			Abandoned

Direct Link:

https://jhu.technologypublisher.com/technology/24561

Inventors:

Category(s):

Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors,

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For Information, Contact:

Vera Sampels

vsampel2@jhu.edu

410-614-0300

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