Treatment of Acute Liver Injury and Hepatic Failure by Mobilization of Bone Marrow Derived Stem Cells

Case ID:

C11054

Acute Liver Failure (ALF), typically due to drug poisoning or viral hepatitis, accounts for around 10,000 deaths per year in the United States. Treatment options are severely limited: supportive observation in the hopes of spontaneous recovery or liver transplant. Liver transplant is an imperfect solution for these patients with extraordinary resource utilization and inferior outcomes. Medical treatments to improve rates of spontaneous recovery are badly needed. It is known that under some circumstances bone marrow derived hematopoietic stem cells (HSCs) can participate in migration to the liver and regeneration of parenchyma. Methods to mobilize HSCs have been developed in other clinical scenarios. Here the inventors report that mobilization of HSCs is life saving in an accepted model of animal Acute Liver Failure. In one aspect, the present invention provides methods of treating a subject with acute liver injury comprising administering to the subject a therapeutically effective amount of at least one stem cell mobilizer. Utilizing this protocol in humans with acute liver failure or perhaps any degree of liver injury may prove profoundly beneficial.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
METHODS OF TREATMENT USING STEM CELL MOBILIZERS	PCT: Patent Cooperation Treaty	European Patent Office	11760152.6	2549992	3/23/2011	8/14/2019	3/23/2031	Granted
METHODS OF TREATMENT USING STEM CELL MOBILIZERS	PCT: Patent Cooperation Treaty	Germany	60 2011 061 271.9	2549992	3/23/2011	8/14/2019	3/23/2031	Granted
METHODS OF TREATMENT USING STEM CELL MOBILIZERS	PCT: Patent Cooperation Treaty	France	11760152.6	2549992	3/23/2011			Granted
METHODS OF TREATMENT USING STEM CELL MOBILIZERS	PCT: Patent Cooperation Treaty	United Kingdom	11760152.6	2549992	3/23/2011	8/14/2019		Granted
METHODS OF TREATMENT USING STEM CELL MOBILIZERS	CON: Continuation	United States	15/254,526	10,086,045	9/1/2016	10/2/2018	3/23/2031	Granted

Direct Link:

https://jhu.technologypublisher.com/technology/24644

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Hepatology > Acute Liver Failure, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Hepatology, Technology Classifications > Therapeutic Modalities,

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For Information, Contact:

Vera Sampels

vsampel2@jhu.edu

410-614-0300

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