Quantitation of GCPII Enzymatic Activity in Human Skin Biopsies as a Clinical Biomarker

Case ID:

C11357

We have identified a unique tissue preparation and enzymatic assay conditions to quatitatively monitor glutamate carboxypeptidase II (GCPII) activity in human skin biopsy samples. This assay can be utilzed as a phanacodynamic (PD) marker in the clinical development of novel GCPII inhibitors. This new assay is a significant improvement over GCPII biomarker assays previously described. Older methods necessitated the collection of CSF and nerve samples, biomatrices diffcult to obtain in clinical studies. Older methods also employed complex spectrometr analyses and provided only indirect measures of GCPII activity by monitoring its substrate and product. The assay described in this disclosure provides a simple and direct measurement of GCPII activity from tissue samples easily asessable in human subjects.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
Quantitation of GCPII Enzymatic Activity in Human Skin Biopsies as a Clinical Biomarker	PCT: Patent Cooperation Treaty	United States	13/977,966	8,771,975	9/12/2013	7/8/2014	1/5/2032	Granted

Direct Link:

https://jhu.technologypublisher.com/technology/24651

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities,

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For Information, Contact:

Nakisha Holder

nickki@jhu.edu

410-614-0300

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