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Broad Spectrum Chemoprotective Activities of Exemstane Against Cancer and Other Chronic Diseases: Synergism with Sulforaphane
Case ID:
C12589
Report of Invention:
6/14/2013
Web Published:
3/17/2017
Estrogens control the growth and development of the majority of breast cancers, the most prevalent malignancies of women in the developed world. Exemestane, a synthetic steroid commonly used clinically to prevent, delay progression of, and treat breast cancer, was designed to inhibit estrogen biosynthesis by aromatase. We have made the unexpected observation that exemestane also has widespread protective activities unrelated to blocking estrogens. Thus, exemestane is potently anti-inflammatory and antioxidant and can thereby protect against development of cancer and chronic degenerative diseases. Moreover, these activities are synergistic with sulforaphane and other cytoprotective phytochemicals. Use of such combinations could therefore provide a valuable strategy for reducing the risk of a variety of other malignancies and age-related chronic diseases.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Broad Spectrum Chemoprotective Activities of Exemstane Against Cancer and Other Chronic Diseases: Synergism with Sulforaphane
ORD: Ordinary Utility
United States
14/333,914
9,585,894
7/17/2014
3/7/2017
7/17/2034
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/24686
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities,
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For Information, Contact:
Heather Curran
hpretty2@jhu.edu
410-614-0300
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