Broad Spectrum Chemoprotective Activities of Exemstane Against Cancer and Other Chronic Diseases: Synergism with Sulforaphane

Estrogens control the growth and development of the majority of breast cancers, the most prevalent malignancies of women in the developed world. Exemestane, a synthetic steroid commonly used clinically to prevent, delay progression of, and treat breast cancer, was designed to inhibit estrogen biosynthesis by aromatase. We have made the unexpected observation that exemestane also has widespread protective activities unrelated to blocking estrogens. Thus, exemestane is potently anti-inflammatory and antioxidant and can thereby protect against development of cancer and chronic degenerative diseases. Moreover, these activities are synergistic with sulforaphane and other cytoprotective phytochemicals. Use of such combinations could therefore provide a valuable strategy for reducing the risk of a variety of other malignancies and age-related chronic diseases.

Category(s):