Hyaluronic Acid Binding Polymer System Transforms Tissue and Biomaterial Surfaces

Case ID:

C12599

We introduce a transformational biomaterial approach to engineering lubrication at the tissue surface that can be applied in a single application. Articular cartilage explants were modified with a synthetic peptide-polymer system designed to non-covalently bind HA to the tissue surface and work synergistically with HA in the local fluid environment. Lubrication properties of chemically-modified tissue surfaces with bound HA were similar to those of native tissue bathed in HA lubricant. Biomaterials-mediated strategies that locally concentrate HA and create a self-healing coating of biological lubricant on tissue surfaces provide physical and biological benefits to treat tissue-lubricating dysfunction.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
Hyaluronic Acid Binding Polymer System Transforms Tissue and Biomaterial Surfaces	PCT: Patent Cooperation Treaty	European Patent Office	14825803.1	3021857	7/16/2014	3/21/2018	7/16/2034	Granted
Hyaluronic Acid Binding Polymer System Transforms Tissue and Biomaterial Surfaces	PCT: Patent Cooperation Treaty	Germany	14825803.1	3021857	7/16/2014	3/21/2018	7/16/2034	Granted
Hyaluronic Acid Binding Polymer System Transforms Tissue and Biomaterial Surfaces	PCT: Patent Cooperation Treaty	France	14825803.1	3021857	7/16/2014	3/21/2018	7/16/2034	Granted
Hyaluronic Acid Binding Polymer System Transforms Tissue and Biomaterial Surfaces	PCT: Patent Cooperation Treaty	United Kingdom	14825803.1	3021857	7/16/2014	3/21/2018	7/16/2034	Granted
Hyaluronic Acid Binding Polymer System Transforms Tissue and Biomaterial Surfaces	PCT: Patent Cooperation Treaty	United States	14/906,111	10,231,991	1/19/2016	3/19/2019	1/22/2033	Granted
BIOMATERIALS COMPRISING HYALURONIC ACID BINDING PEPTIDES AND EXTRACELLULAR MATRIX BINDING PEPTIDES FOR HYALURONIC ACID RETENTION AND TISSUE ENGINEERING APPLICATIONS	DIV: Divisional	United States	16/260,191	11,135,240	1/29/2019	10/5/2021	1/22/2033	Granted
BIOMATERIALS COMPRISING HYALURONIC ACID BINDING PEPTIDES AND EXTRACELLULAR MATRIX BINDING PEPTIDES FOR HYALURONIC ACID RETENTION AND TISSUE ENGINEERING APPLICATIONS	CON: Continuation	United States	17/459,201	11,944,637	8/27/2021	4/2/2024	9/26/2033	Granted

Direct Link:

https://jhu.technologypublisher.com/technology/24688

Inventors:

Category(s):

Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices,

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For Information, Contact:

Heather Curran

hpretty2@jhu.edu

410-614-0300

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