🔍
MRI-guided Intraarterial Catheter-based Method for Predicting Territory of Local Blood Brain Barrier Opening
Case ID:
C12960
Report of Invention:
3/18/2014
Web Published:
3/17/2017
Unmet Need:
The blood-brain barrier (BBB) is a major hurdle to therapeutic agents reaching the brain. Osmolar agents can be used to create openings in the BBB, but this technique is clinically limited because of wide variability in the size and location of the resulting openings. JHU inventors have developed a system and highly controlled procedure to meet the significant unmet need of predictable creation of therapeutically effective BBB openings order to administer effective and localized treatment.
• Predictable procedure provides added control and reproducibility of BBB openings opening created by osmotic agents which can be targeted to specific brain regions
• Procedure validated by real-time non-invasive MRI methods
Technology Overview:
JHU scientists developed a real time method of using MRI-guided intra-arterial catheters to administer an osmotic agent and a contrast agent to identify and determine a transcatheter perfusion area in the BBB which would be an optimal BBB opening position to administer therapeutics to the brain. To perform this therapeutic method. JHU scientists developed a computer-implemented system for modeling an optimized BBB opening which includes an intra-arterial catheter for perfusing the BBB with a hyperosmolar agent, a real time MR imaging device for visualizing BBB perfusion. The system uses user- input data to construct a model for optimized BBB opening.
Stage of Development:
Pre-clinical animal data
Publications:
J Cereb Blood Flow Metab. 2016 Mar;36(3):569-75
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
MRI-GUIDED INTRAARTERIAL CATHETER-BASED METHOD FOR PREDICTING TERRITORY OF LOCAL BLOOD BRAIN BARRIER OPENING
PCT: Patent Cooperation Treaty
United States
15/311,696
10,478,120
11/16/2016
11/19/2019
5/17/2035
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/24711
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices,
Get custom alerts for techs in these categories/from these inventors:
Subscribe for JHTV Updates
For Information, Contact:
Lisa Schwier
lschwie2@jhu.edu
410-614-0300
Save This Technology:
Bookmark this page
Download as PDF
JHTV Home
|
Search
|
Login/Subscribe
2017 - 2022 © Johns Hopkins Technology Ventures. All Rights Reserved. Powered by
Inteum