Formulation Method and Use of Highly Stable Biodegradable Gene Vector Platforms Capable of Overcoming Various Biological Barriers

JHU researchers have formulated compact, colloidally stable gene carriers that have a dense surface coverage of hydrophilic and neutrally charged PEG. These gene vectors stably retain their physicochemical characteristics over at least a week in aqueous solution and are highly stable in physiological solutions. Moreover, they demonstrate the ability to penetrate physiological barriers such as airway mucus and brain tissue/tumor allowing for widespread distribution and high level transgene expression in vivo. These advantages provide the opportunity to expand this highly efficient, tailorable and biodegradable gene delivery platform in vivo and render it more compatible with clinical applications.

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