Intranasal Administration of Glutamate Carboxypeptidase (GCP-II) Inhibitors for Enhanced Brain Delivery

Case ID:

C13346

Inventors have developed a novel method to enhance the penetrance of multiple GCPII inhibitors which were developed by the inventor and Dr. Pomper at JHU. This method demonstrated improved brain penetrance in rodents. The penetrance of a specific GCPII inhibitor showed significant brain penetrance in non-human primates and inhibited GCPII activity in the brain in rodents.
US Patent application filed July 2017 claiming priority to PCT application published as WO 2016/112382

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
INTRANASAL ADMINISTRATION OF GLUTAMATE CARBOXYPEPTIDASE (GCP-II) INHIBITORS	CON: Continuation	United States	17/737,229		5/5/2022			Pending

Direct Link:

https://jhu.technologypublisher.com/technology/24780

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities,

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For Information, Contact:

Nakisha Holder

nickki@jhu.edu

410-614-0300

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