Synthesis of poly(β-amino ester)-co-polyethylene glycol (PEG-PBAE-PEG) polymer for gene and drug delivery

Case ID:

C13427

Non-viral vectors are widely investigated due to their ability to safely and effectively deliver exogenous genes and potentially cure diseases of genetic origin. Much portion of the ongoing research in the field is also dedicated to further optimize the existing vectors for in vivo applications. This work describes new compositions of matter of polyethylene glycol (PEG) - poly(ß-amino ester) (PBAE) co-polymers through a novel synthesis scheme. DNA , siRNA , and other cargos associate with a blend of PEGylated PBAE and unmodified PBAE to form stable particles for drug and gene delivery. PEGylated PBAE, an amphiphilic polymer, also forms micelles that can deliver hydrophobic drugs.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
Synthesis of poly(β-amino ester)-co-polyethylene glycol (PEG-PBAE-PEG) polymer for gene and drug delivery	PCT: Patent Cooperation Treaty	United States	15/561,869	11,401,380	9/26/2017	8/2/2022	9/2/2039	Granted
POLY(BETA-AMINO ESTER)-CO-POLYETHYLENE GLYCOL (PEG-PBAE-PEG) POLYMERS FOR GENE AND DRUG	CON: Continuation	United States	17/865,822		7/15/2022			Pending

Direct Link:

https://jhu.technologypublisher.com/technology/24796

Inventors:

Category(s):

Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities,

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For Information, Contact:

Nakisha Holder

nickki@jhu.edu

410-614-0300

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