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Synthesis of poly(β-amino ester)-co-polyethylene glycol (PEG-PBAE-PEG) polymer for gene and drug delivery
Case ID:
C13427
Report of Invention:
2/9/2015
Web Published:
3/17/2017
Non-viral vectors are widely investigated due to their ability to safely and effectively deliver exogenous genes and potentially cure diseases of genetic origin. Much portion of the ongoing research in the field is also dedicated to further optimize the existing vectors for in vivo applications. This work describes new compositions of matter of polyethylene glycol (PEG) - poly(ß-amino ester) (PBAE) co-polymers through a novel synthesis scheme. DNA , siRNA , and other cargos associate with a blend of PEGylated PBAE and unmodified PBAE to form stable particles for drug and gene delivery. PEGylated PBAE, an amphiphilic polymer, also forms micelles that can deliver hydrophobic drugs.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Synthesis of poly(β-amino ester)-co-polyethylene glycol (PEG-PBAE-PEG) polymer for gene and drug delivery
PCT: Patent Cooperation Treaty
United States
15/561,869
11,401,380
9/26/2017
8/2/2022
9/2/2039
Granted
POLY(BETA-AMINO ESTER)-CO-POLYETHYLENE GLYCOL (PEG-PBAE-PEG) POLYMERS FOR GENE AND DRUG
CON: Continuation
United States
17/865,822
7/15/2022
Pending
Direct Link:
https://jhu.technologypublisher.com/technology/24796
Inventors:
Category(s):
Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities,
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For Information, Contact:
Nakisha Holder
nickki@jhu.edu
410-614-0300
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