Synthesis of poly(β-amino ester)-co-polyethylene glycol (PEG-PBAE-PEG) polymer for gene and drug delivery

Case ID:
C13427
Non-viral vectors are widely investigated due to their ability to safely and effectively deliver exogenous genes and potentially cure diseases of genetic origin. Much portion of the ongoing research in the field is also dedicated to further optimize the existing vectors for in vivo applications. This work describes new compositions of matter of polyethylene glycol (PEG) - poly(ß-amino ester) (PBAE) co-polymers through a novel synthesis scheme. DNA , siRNA , and other cargos associate with a blend of PEGylated PBAE and unmodified PBAE to form stable particles for drug and gene delivery. PEGylated PBAE, an amphiphilic polymer, also forms micelles that can deliver hydrophobic drugs.
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Synthesis of poly(β-amino ester)-co-polyethylene glycol (PEG-PBAE-PEG) polymer for gene and drug delivery PCT: Patent Cooperation Treaty United States 15/561,869 11,401,380 9/26/2017 8/2/2022 9/2/2039 Granted
POLY(BETA-AMINO ESTER)-CO-POLYETHYLENE GLYCOL (PEG-PBAE-PEG) POLYMERS FOR GENE AND DRUG CON: Continuation United States 17/865,822   7/15/2022     Pending
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For Information, Contact:
Nakisha Holder
nickki@jhu.edu
410-614-0300
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