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Glutamine Antagonists for the Treatment of Cognitive Deficits, including NeuroAIDs
Case ID:
C13696
Report of Invention:
6/15/2015
Web Published:
3/17/2017
Some glutamine antagonists have been shown to have anti-cancer activities in multiple preclinical and clinical studies. However the toxicity of the glutamine antagonists at doses necessary for their anticancer effects have hampered their clinical development. Herein we describe a completely novel use for the glutamine antagonists. Using a prototype glutamine antagonist, we show for the first time, at doses significantly less that that used for its anticancer efficacy, that it can selectively abrogate cognitive deficits in the EcoHIV model of neuroAIDs. We show supporting PK and biomarker data. These data predict the use of glutamine antagonists (or their prodrugs or analogs) for the treatment of cognitive deficits in general, and specifically for NeuroAIDs.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
GLUTAMINE ANTAGONISTS FOR THE TREATMENT OF COGNITIVE DEFICITS
CIP: Continuation-in-part
United States
15/884,974
11,110,104
1/31/2018
9/7/2021
7/29/2036
Granted
GLUTAMINE ANTAGONISTS FOR THE TREATMENT OF COGNITIVE DEFICITS AND PSYCHIATRIC DISORDERS
CON: Continuation
United States
18/479,357
10/2/2023
Pending
Direct Link:
https://jhu.technologypublisher.com/technology/24837
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities,
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For Information, Contact:
Nakisha Holder
nickki@jhu.edu
410-614-0300
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