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Method of Fast Imaging of NMR Parameters with Variably-accelerated Sensitivity Encoding (vSENSE)
Case ID:
C14010
Report of Invention:
3/4/2016
Web Published:
3/17/2017
Unmet Need:
Long scan times due to its requirement that multiple saturation-offset image frames be acquired is the underlying reason that widespread clinical use of chemical exchange saturation transfer (CEST) imaging is hampered.
Technology Overview:
The invention is a novel method that fully samples one CEST saturation frame, then undersamples the other frames variably. The fully-sampled frame, in conjunction with newly proposed incoherence absorption and artifact suppression strategies, improves the accuracy of sensitivity maps and permits higher acceleration factors for the other undersampled frames than regular SENSE. This technology is validated in a phantom, a normal volunteer and eight brain tumor patients at 3 Tesla. This new method enabled twice the acceleration and generated more accurate images than conventional SENSE.
Stage of Development:
Prototype is currently being tested and provisional patents have been filed.
Publications:
https://www.ncbi.nlm.nih.gov/labs/articles/27364631/
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
METHOD OF FAST IMAGING OF NMR PARAMETERS WITH VARIABLY-ACCELERATED SENSITIVITY ENCODING
PCT: Patent Cooperation Treaty
United States
16/091,785
10,908,235
10/5/2018
2/2/2021
8/3/2037
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/24886
Inventors:
Category(s):
Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices,
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For Information, Contact:
Louis Mari
lmari3@jhu.edu
410-614-0300
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