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Easy-to-use Micro-fabricated Device for the Analysis of Mechanical and Chemical Properties of Complex Mechanically Controlled Tissue Constructs
Case ID:
C13594
Report of Invention:
5/1/2015
Web Published:
4/20/2017
Unmet need:
There is a need to bridge the gap between simplistic
in-vitro
studies and expensive, complex
in-vivo
studies to obtain meaningful pre-clinical data from a representative cellular environment and. One promising method is to use 3D cell cultures, or organ-chips, that reconstitute various functionalities of human organs in a microenvironment. These platforms allow extensive control on the cellular microenvironment while recapitulating important physiologic conditions. These platforms can be used to study mechanisms and new treatments for diseases such as asthma and brain cancer. The device platform combines long term cell culture tissue modeling with biological, microrheological, or mechanical studies.
Technical Details:
The innovation is a multi-layer silicone elastomer device chip platform that mimics important aspects of human tissues or organs, whereby two or more cell types can interact through porous membranes that can be inflexible or flexible. The device allows long-term cell growth using standard culturing techniques, and can be readily adopted for various biomedical research purposes. It is user friendly and does not require technical expertise in microfluidics. The platform further allows application of a controlled pressure on cells to induce compressive or tensile stress on the cells. JHU inventors successfully applied the technology to analyze conditions related to human airways. The device can potentially speed development of disease therapeutics. JHU inventors have developed a manufacturing technique that makes it easier and cheaper to construct these multi-layer silicone elastomer devices in comparison to other 3D cell culture, or organ-chips devices.
Publications
Lab Chip. 2016 Oct 18;16(21):4152-4162.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Easy-to-use Micro-fabricated Device for the Analysis of Mechanical and Chemical Properties of Complex Mechanically Controlled Tissue Constructs
PCT: Patent Cooperation Treaty
PCT
PCT/US2016/040695
7/1/2016
Expired
DEVICE AND METHOD FOR ANALYSIS OF TISSUE CONSTRUCTS
PCT: Patent Cooperation Treaty
United States
15/739,639
11,066,630
12/22/2017
7/20/2021
8/17/2037
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/25102
Inventors:
Category(s):
Technology Classifications > Research Tools,
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For Information, Contact:
Heather Curran
hpretty2@jhu.edu
410-614-0300
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