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Cornea Mimetic Biomaterials: Vitrified Collagen-cyclodextrin Implants
Case ID:
C13806
Report of Invention:
9/9/2015
Web Published:
7/13/2018
Unmet Need:
Due to eye injuries and ocular diseases such as keratitis and keratoconus, nearly 5 million patients in the world suffer from corneal blindness. The cornea is a transparent multilayered tissue of the eye that consists of epithelial and endothelial layers and helps focus the light on the retina. However, injuries to the cornea can cause corneal scarring which results in a haze that impairs vision. There is a limited availability of donor corneas especially in developing regions of Asia and Africa which translates to a low percentage of individuals that can receive treatment. Current standards of care include donor corneas and synthetic corneas. Donor corneas, which are considered the best corneal replacement, have issues with availability, storage, and distribution. Synthetic corneas can successfully correct for refractive properties of the damaged corneas; however, because they are synthetic polymer based, they do not support tissue remodeling or integration into the patient’s body which can lead to complications. There is a need to develop synthetic alternatives that supports tissue remodeling and replicates the physical properties of a native healthy cornea.
Technology Overview:
Researchers at Hopkins have developed a corneal mimetic structure. Normal corneas contain high amounts of proteoglycans, which play a critical role in corneal transparency by regulating the collagen fiber diameter and spacing. However, it is difficult to derive a large amount of purified proteoglycans. In its place, investigators substituted cyclodextrins, circular sugar molecules that are easy to synthesis and are routinely used in other biological applications. The cyclodextrin-collagen matrix forms a thick, transparent and mechanically strong collagen-based composition. This biocomposition mimics the multilayered structure of the cornea, with different layers promoting different biological properties. It also supports tissue remodeling that synthetic corneas are unable to do, making this invention a practical and functional alternative for corneal regeneration. This synthetic biocomposition also addresses issues of limited availability of donor corneas.
Stage of Development:
Results from a rabbit model demonstrate cyclodextrin-collagen implants can serve as corneal substitutes with high transparency, ease of suturability and biomimetic ultrastructure.
Publications:
N/A
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Cornea Mimetic Biomaterials: Vitrified Collagen-cyclodextrin Implants
PCT: Patent Cooperation Treaty
China
201580028165.2
ZL106456833
9/10/2015
1/10/2020
9/10/2035
Granted
Cornea Mimetic Biomaterials: Vitrified Collagen-cyclodextrin Implants
PCT: Patent Cooperation Treaty
European Patent Office
15889426.1
3285819
9/10/2015
11/4/2020
9/10/2035
Granted
Cornea Mimetic Biomaterials: Vitrified Collagen-cyclodextrin Implants
PCT: Patent Cooperation Treaty
India
201617036411
513290
9/10/2015
2/21/2024
9/10/2035
Granted
Cornea Mimetic Biomaterials: Vitrified Collagen-cyclodextrin Implants
PCT: Patent Cooperation Treaty
France
15889426.1
3285819
9/10/2015
11/4/2020
9/10/2035
Granted
Cornea Mimetic Biomaterials: Vitrified Collagen-cyclodextrin Implants
PCT: Patent Cooperation Treaty
Germany
60 2015 061 699.5
3285819
9/10/2015
11/4/2020
9/10/2035
Granted
Cornea Mimetic Biomaterials: Vitrified Collagen-cyclodextrin Implants
PCT: Patent Cooperation Treaty
United Kingdom
15889426.1
3285819
9/10/2015
11/4/2020
9/10/2035
Granted
CORNEA MIMETIC BIOMATERIALS: VITRIFIED COLLAGEN-CYCLODEXTRIN IMPLANTS
PCT: Patent Cooperation Treaty
United States
15/306,146
10/24/2016
Pending
Direct Link:
https://jhu.technologypublisher.com/technology/28105
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Keratoconus,
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For Information, Contact:
Heather Curran
hpretty2@jhu.edu
410-614-0300
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