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MicroRNA Delivery as a Novel Therapeutic Strategy for Liver Cancer
Case ID:
C10568
Report of Invention:
12/2/2008
Web Published:
7/13/2018
Unmet need
Over 500,000 people are diagnosed with liver cancer worldwide each year. According the American Cancer Society, liver cancer resists most chemotherapy drugs and the most effective agents shrink less than 1 in 5 tumors and generally for only a short time. Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage making it difficult to cure. Further, the efficacy of current therapeutic regimen is reduced due to the presence of active drug-metabolizing pathways and multi-drug resistance transporters. There is need in art for alternative approaches for treatment of HCC.
Technology overview
Researchers at the Johns Hopkins University and Nationwide Children’s Hospital have developed a method to treat liver cancer comprising a method to systemically deliver therapeutic microRNAs. They have discovered that a microRNA that is normally expressed at high levels in various tissues exhibits reduced expression in liver tumors or hepatocellular carcinomas (HCC). They have developed a method to treat and suppress HCC utilizing systemic delivery of a specific microRNA in an adeno-associated virus (AAV) system which additionally simultaneously expresses eGFP for easy assessment of target tissue transduction. When the AAV-mediated microRNA is delivered systemically to mice, the microRNA is expressed at high levels in the liver without toxic effects to normal mice while suppressing tumors in tumor bearing mice. This method offers a therapeutic mechanism to treat and suppress liver cancer that minimizes toxicity to patients.
Stage of development
Pre-clinical
Publications
Kota J et al. Cell 137(6), 1005–17, 2009
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
COMPOSITIONS AND METHODS FOR TREATING HEPATIC NEOPLASIA
PCT: Patent Cooperation Treaty
United States
13/132,783
8,729,041
8/24/2011
5/20/2014
12/2/2029
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/28107
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Hepatology, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Liver Cancer,
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For Information, Contact:
Michael Woods
mwoods19@jh.edu
410-614-0300
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