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C34 triols in the treatment or prevention of inflammatory disorders in children and adults with a focus on necrotizing enterocolitis
Case ID:
C14916
Report of Invention:
8/10/2017
Web Published:
10/19/2018
Unmet Need
Necrotizing enterocolitis (NEC) is the leading cause of death and disability in premature infants. The disease is characterized by a bacterial infection in the intestines that quickly progresses to organ death if untreated. Current treatment of NEC entails surgically removing the diseased parts of the intestine. However, this procedure leads to death in half of all patients and complications later in life. Poor outcomes in treating NEC has led Hopkins researchers to investigate non-invasive treatments of this disease.
Technology Overview
Recently, Hopkins researchers have identified that the premature infant intestine contains a “switch” called Toll Like Receptor 4 (or TLR4), which is “turned on” in premature babies by bacteria and leads to NEC. Using computer assisted drug design, Hopkins researchers recently identified a novel molecule, called “C34”, which can safely “shut off” the TLR4 switch after oral administration. The invention disclosed herein presents additional C34-related structures that show efficacy in relevant mouse models for the treatment or prevention of inflammatory disorders with a focus on NEC.
Stage of Development
Hopkins researchers have shown that the oral administration of a C34 analog successfully “shuts off” TLR4 in well validated mice and piglet models.
Publications
Hackman et al.,
Journal of Pediatric Surgery
, 2018.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISORDERS
CIP: Continuation-in-part
United States
15/996,383
10,668,092
6/1/2018
6/2/2020
9/26/2031
Granted
COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISORDERS
CON: Continuation
United States
16/854,196
11,413,299
4/21/2020
8/16/2022
11/12/2030
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/29043
Inventors:
Category(s):
Clinical and Disease Specializations > Inflammation > Necrotizing Enterocolitis, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules,
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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