🔍
System and Method for Phase Dependent Brain Neuromodulation
Case ID:
C14707
Report of Invention:
4/6/2017
Web Published:
8/2/2019
Unmet Need
Neuromodulation is a technology that involves the spatiotemporal alteration of brain activity with electrical, magnetic, or chemical stimulation. Neuromodulation devices can be implantable or non-implantable and target specific areas of the body in order to restore proper activity to a malfunctioning nervous system most commonly seen in movement disorders and psychiatric conditions.
Current state of the art neuromodulation systems deliver a constant pulse stimulation that is applied continuously or triggered by abnormal brain activity. While these methods have demonstrated clinical utility, they are also inflexible and unable to change their pulse parameters in real time as patients’ neural oscillations change.
Technology Overview
Johns Hopkins researchers developed a system that delivers real-time neural electrical stimulations customized to the patients’ pathophysiological brain activity. This device can detect and detect rhythmic electrical activity in the brain. The system provides phase-specific stimulation triggering pulses. Specifically, this system uses a real time, parametric spectral estimation method for modeling neural oscillations by using a band-pass optimized autoregressive technique to detect transient rhythmic activity, and times stimulation pulses relative to the predetermined phases of that activity. The structure of the system is designed in such a way that the entire framework can be implemented with system on a chip (SoC) technology.
Stage of Development
A prototype device has been developed.
Publications
Salimpour Y, Anderson WS. Front. Neurosci. 2019 Feb, 13(125)
Chen LL et al. IEEE Trans Biomed Eng. 2013 Mar; 60(3): 753–762.
Chen LL et al. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3087-90.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
PHASE-DEPENDENT BRAIN NEUROMODULATION OF PHASE-AMPLITUDE COUPLING
PCT: Patent Cooperation Treaty
United States
17/310,445
11,975,199
8/3/2021
5/7/2024
11/20/2040
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/35285
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices,
Get custom alerts for techs in these categories/from these inventors:
Subscribe for JHTV Updates
For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
Save This Technology:
Bookmark this page
Download as PDF
JHTV Home
|
Search
|
Login/Subscribe
2017 - 2022 © Johns Hopkins Technology Ventures. All Rights Reserved. Powered by
Inteum