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Non-immunosuppressive FK506 analogs and use thereof

Case ID:
C15634
Unmet Need
Chronic, nonhealing wounds are estimated to affect approximately 2% of the general population, and the cost of caring for these wounds exceeds $50 billion per year. These costs are expected to rise due to the increasing prevalence of diabetes and other diseases that hinder wound healing. Chronic infections increase morbidity and mortality in affected individuals and reduce quality of life. Consequently, novel therapeutics that accelerate wound healing are needed.
 
Technology Overview
The inventors have previously demonstrated that combination therapy with two drugs, FK506 and AMD3100, synergistically enhances wound healing in a diabetic mouse model. FK506 contributes to wound healing by activating BMP signaling through its binding and inhibition of FKB12. However, FK506 is a potent immunosuppressant with off target effects. To overcome this limitation, the inventors designed and synthesized a series of FK506 analogs that are not immunosuppressive. Importantly, these inhibitors retained their ability to bind FKB12 and activate BMP signaling. The inventors tested the FK506 analogs in combination with AMD3100 and observed the same acceleration of wound healing that was observed with FK506.
 
Stage of Development
The inventors synthesized FK506 analogs and confirmed their ability to synergize with AMD3100 to accelerate wound healing in a diabetic mouse model.
 
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Israel 285085 285085 1/23/2020 2/3/2025 1/23/2040 Granted
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Canada 3,127,613   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Australia 2020211994   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Mexico MX/A/2021/008824 413272 1/23/2020 5/21/2024 1/23/2040 Granted
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty South Africa 2021/05759   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Korea (South) 10-2021-7026390   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty European Patent Office 20746065.0 3914599 1/23/2020 11/27/2024 1/23/2040 Granted
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty China 2020800221718 ZL202080022171.8 1/23/2020 1/17/2025 1/23/2040 Granted
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Japan 2021-543343   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty India 202117035679   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Hong Kong 62022053073.2 HK40063831 1/23/2020 1/10/2025 1/23/2040 Granted
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF DIV: Divisional Mexico MX/a/2024/006177   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Belgium 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Denmark 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty France 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Germany 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Ireland 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Italy 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Liechtenstein 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Netherlands 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Spain 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Sweden 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Switzerland 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty Turkey 2025/001413 3914599 1/23/2020 11/27/2024   Granted
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty United Kingdom 20746065.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF DIV: Divisional European Patent Office 24208670.0   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF DIV: Divisional China 202411953070.9   1/23/2020     Pending
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF PCT: Patent Cooperation Treaty United States 17/424,441   7/20/2021     Pending
Direct Link:
https://jhu.technologypublisher.com/technology/35368
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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