Unmet NeedChronic, nonhealing wounds are estimated to affect approximately 2% of the general population, and the cost of caring for these wounds exceeds $50 billion per year. These costs are expected to rise due to the increasing prevalence of diabetes and other diseases that hinder wound healing. Chronic infections increase morbidity and mortality in affected individuals and reduce quality of life. Consequently, novel therapeutics that accelerate wound healing are needed.
Technology OverviewThe inventors have previously demonstrated that combination therapy with two drugs, FK506 and AMD3100, synergistically enhances wound healing in a diabetic mouse model. FK506 contributes to wound healing by activating BMP signaling through its binding and inhibition of FKB12. However, FK506 is a potent immunosuppressant with off target effects. To overcome this limitation, the inventors designed and synthesized a series of FK506 analogs that are not immunosuppressive. Importantly, these inhibitors retained their ability to bind FKB12 and activate BMP signaling. The inventors tested the FK506 analogs in combination with AMD3100 and observed the same acceleration of wound healing that was observed with FK506.
Stage of DevelopmentThe inventors synthesized FK506 analogs and confirmed their ability to synergize with AMD3100 to accelerate wound healing in a diabetic mouse model.
Title |
App Type |
Country |
Serial No. |
Patent No. |
File Date |
Issued Date |
Expire Date |
Patent Status |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Israel |
285085 |
285085 |
1/23/2020 |
2/3/2025 |
1/23/2040 |
Granted |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Canada |
3,127,613 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Australia |
2020211994 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Mexico |
MX/A/2021/008824 |
413272 |
1/23/2020 |
5/21/2024 |
1/23/2040 |
Granted |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
South Africa |
2021/05759 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Korea (South) |
10-2021-7026390 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
European Patent Office |
20746065.0 |
3914599 |
1/23/2020 |
11/27/2024 |
1/23/2040 |
Granted |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
China |
2020800221718 |
ZL202080022171.8 |
1/23/2020 |
1/17/2025 |
1/23/2040 |
Granted |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Japan |
2021-543343 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
India |
202117035679 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Hong Kong |
62022053073.2 |
HK40063831 |
1/23/2020 |
1/10/2025 |
1/23/2040 |
Granted |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
DIV: Divisional |
Mexico |
MX/a/2024/006177 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Belgium |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Denmark |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
France |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Germany |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Ireland |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Italy |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Liechtenstein |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Netherlands |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Spain |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Sweden |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Switzerland |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
Turkey |
2025/001413 |
3914599 |
1/23/2020 |
11/27/2024 |
|
Granted |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
United Kingdom |
20746065.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
DIV: Divisional |
European Patent Office |
24208670.0 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
DIV: Divisional |
China |
202411953070.9 |
|
1/23/2020 |
|
|
Pending |
NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF |
PCT: Patent Cooperation Treaty |
United States |
17/424,441 |
|
7/20/2021 |
|
|
Pending |