Method for the Preparation of Non-live Chromobacterium Biopesticide

Case ID:
C16318

Unmet Need: Mosquitoes and other insect vectors represent a major global health threat by transmission of diseases such as malaria, dengue and zika. With increasing insecticide resistance and the negative environmental impact of chemicals, there is an urgent need for novel, eco- friendly insect vector control methods.

 

Technical Details: Johns Hopkins researchers have developed a biopesticide using a natural soil bacterium, Chromobacterium (Csp_P) that is active against multiple stages of insect vectors of human disease, as well as agricultural pest insects. A non-live air-dried preparation of Csp_P rapidly kills target insects by ingestion through an artificial nectar or other food bait.  This biodegradable natural product -based biopesticide foregoes use of environmentally harsh chemicals. In addition, production is simple and cost-effective, and the biopesticide has a remarkable shelf-life at storage conditions as well as when deployed in the field. Semi-field trials were conducted and demonstrated high efficacy against field-derived mosquitoes in natural breeding waters, indicating suitability of the biopesticide for use at natural conditions of disease endemic areas. Overall, the Csp_P -based biopesticide represents a novel insecticide for the control of multiple mosquito species and other insect pests.

 

Value Proposition:

 

·        Effective against both larval and adult stages of multiple mosquito species that vector human pathogens

·        Effective against agricultural pests.

·        Delivery via laval pellets and artificial nectar feeding achieves effective mosquito control

·        Simple and cost-effective production

·        Long shelf life and stability

 

Looking for Partners to: Develop & commercialize the technology as a possible broad-spectrum biopesticide to control transmission of vector-borne diseases.

 

Stage of Development: Pre-Clinical

 

Data Availability: Animal data

 

Inventors: George Dimopoulos, Eric Caragata, Raul Saraiva

 

Patent Status: Pending

 

Associated technology: For more information please see related technology C12694.

 

Publication(s): Caragata EP, Otero LM, Carlson JS, Dizaji NB, Dimopoulos G. (2020) A nonlive preparation of Chromobacterium sp. Panama (Csp_P) is a highly effective larval mosquito biopesticide. AEM 86(11): e00240-20.

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
METHODS FOR THE PREPARATION OF NON-LIVE CHROMOBACTERIUM BIOPESTICIDE PCT: Patent Cooperation Treaty United States 18/249,293   4/17/2023     Pending
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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