Use of Sulforaphane to inhibit Coronaviruses such as SARS-CoV-2 and to treat coronavirus diseases such as COVID19

Case ID:
C16492
Disclosure Date:
7/29/2020

Inventor(s): Lorraine Brando, Alvaro Ordonez, Robert Yolken, Sanjay Jain


Unmet Need

COVID-19 is a worldwide problem, and infection rates continue to rise. Therefore, more therapies and prophylactics are urgently needed to suppress the rise of confirmed cases and reduce the mortality rate.  


Technology Overview

Johns Hopkins researchers have invented a method to prevent and treat COVID-19. They proposed the use of sulforaphane (SF), a natural compound found in cruciferous vegetables (i.e. broccoli, kale), for COVID-19 prevention and treatment. Their in vitro experiments showed that SF inhibits SARS-CoV-2 replication, demonstrating the potential of SF to be a relatively cheap and widely available prophylactic and therapeutic against COVID-19.


Stage of Development

This technology is under pre-clinical development.


publication:

https://www.biorxiv.org/content/10.1101/2021.03.25.437060v1


https://www.nature.com/articles/d41586-022-01923-5

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Methods for Inhibiting Coronaviruses Using Sulforaphane PCT: Patent Cooperation Treaty PCT PCT/2022/014267   1/28/2022     Pending
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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