Non-invasive Left Ventricular End Diastolic Pressure (LVEDP) Measurement for In-hospital, Outpatient and Home Diagnostic Monitoring

Unmet Need
Both physicians and surgeons rely heavily on the cardiac chamber pressures, especially that in the left ventricle, to assess the fluid volume status of patients and heart function pre and post procedures in the in-hospital setting, outpatient clinics or when patients are at their home.  Current methodologies are either invasive in nature with associated complications or non-suitability for specific patient types, or they allow only measurement of surrogate parameters in lieu of LVEDP.

Technology Overview
This disclosure presents a novel approach of non-invasively establishing the LVEDP by using:
1)    Specific hemodynamic relationships
2)    Measurement techniques and systems to measure key parameters
3)    Algorithmic approach to use the measured parameters and hemodynamic relationships to derive the LVEDP.

Stage of Development
Both animal studies (in adult pigs) and retrospective analysis of human catheterization data was performed to validate the algorithm.

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