Nanoparticle Modification of Human Adipose-derived Mesenchymal Stem Cells for Brain Cancer and Other Neurological Diseases

Human Adipose-derived Mesenchymal Stem Cells can be engineered to synthesize and release anti-tumor proteins and therefore can be used as “Trojan Horses”. The inventors have created a novel technology which encompasses a solution containing biodegradable, polymeric nanoparticles that is combined with Freshly-extracted Adipose Tissue (F.A.T.) (from a patient, autologous cells). This technology non-virally engineers the F.A.T. including the primary hAMSCs contained within the F.A.T to secrete anti-cancer proteins while maintaining the cells' ability to migrate toward tumor cells. For future clinical application, the nanoparticles could be added ex vivo to hAMSCs obtained from patient fat after culturing for a few days and then the autologous cells administered IV as a treatment. Alternatively, the nanoparticle solution can be added to F.A.T. with the resulting mixture re-administered during surgery, without the cells being processed. This technology is more easily translatable than cell therapy approaches that require cell culturing and many FDA regulations. This is a revolutionary new way of treating patients with brain cancer and facilitating personalized medicine.

Category(s):