Unmet Need / Invention Novelty: Nitroxyl (HNO) has high biological significance with utility in both chemical studies and medical applications. However, current methods for generating HNO require either donor molecules in solution or extreme experimental conditions and result in HNO dimerization that yields undesired byproducts. There is an unmet need to develop a more controlled way to produce HNO.
Technical Details: Johns Hopkins researchers have developed a novel method to efficiently generate gaseous HNO in a controlled way. The method consists of reacting a solid HNO donor, Piltoy’s acid, with a gaseous base, such as ammonia, to quickly yield gaseous HNO. Production of HNO by this method obviates the need for liquid phases or extreme experimental conditions and is envisioned for use in chemical reactions and medical applications such as drug delivery and HNO therapy.
Value Proposition:
- Fast and economical generation of HNO in the gas phase
- Minimizes HNO dimerization and byproducts to result in HNO as the main species
- Utility in chemical reactions
- Broadly applicable to diseases and conditions responsive to HNO therapy including cardiovascular disease, ischemia/reperfusion injury, pulmonary hypertension, cancer, alcoholism, vascular dysfunction, and bacterial infection
Looking for Partners to: Develop & commercialize as a novel method for generating HNO in the gas phase for chemical and medical applications.
Stage of Development: Pre-Clinical
Data Availability: Proof-of-concept data including generation of HNO in the gas phase
Inventors: John Toscano, Jessica Zarenkiewicz, Guillermo Carrone, Agostina Mazzeo, Ernesto Marceca, Juan Pellegrino, Fabio Doctorovich, & Sebastian Suarez
Publication(s): Carrone G, Mazzeo A, Marceca E, et al. Solid-gas reactions for nitroxyl (HNO) generation in the gas phase. J Inorg Biochem. 2021;223:111535. doi:10.1016/j.jinorgbio.2021.111535
