Unmet Need
Worldwide, an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths occurred in 2020. Currently, techniques exist to isolate DNA, RNA, and proteins from cells to identify cancer. One such technique is Expression microdissection, which is an efficient and user-independent method to isolate DNA, RNA, protein or other materials from tissues placed on glass slides. This method does pose challenges, one being that it relies on commercial ethylene vinyl acetate (EVA) membrane, which does not allow for optimal biomaterial recovery efficiency. These membranes are cross-linked and insoluble resulting in poor yield of collected material, which leads to inefficient testing and diagnosis. Therefore, there is a strong need to develop a more effective novel non-cross-linked ethylene vinyl acetate (EVA) membrane.
Technology Overview
Researchers at Johns Hopkins University have developed a novel non-cross-linked ethylene vinyl acetate (EVA) membrane that is impregnated with fullerenes allowing for specific isolation of target pigmented structures and optimal collection of transferred material through membrane solubility in phenol chloroform.
Stage of Development
The membranes have been fully optimized.
Publication
N/a
