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Design, Synthesis and Structure-activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors
Case ID:
C12897
Report of Invention:
2/6/2014
Web Published:
6/9/2022
This invention describes a set of novel small molecules that inhibit RNA polymerase I. RNA polymerase I (Pol I) governs the transcription of ribosomal RNAs, which are needed for building and function of the ribosomes. These ribosynthetic activities are greatly increased in cancer cells, and Pol I transcription rate is commonly deregulated in human cancers. The small molecules described here inhibit Pol I and cause degradation of RPA194, the catalytic subunit driving the Pol I activity. The molecules inhibit the growth of cancer cells and hold promise as new anticancer agents.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Design, Synthesis and Structure-activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors
PCT: Patent Cooperation Treaty
European Patent Office
15765295.9
3119781
3/20/2015
9/16/2020
3/20/2035
Granted
Design, Synthesis and Structure-activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors
PCT: Patent Cooperation Treaty
France
15765295.9
3119781
3/20/2015
9/16/2020
3/20/2035
Granted
Design, Synthesis and Structure-activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors
PCT: Patent Cooperation Treaty
Germany
15765295.9
3119781
3/20/2015
9/16/2020
3/20/2035
Granted
Design, Synthesis and Structure-activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors
PCT: Patent Cooperation Treaty
United Kingdom
15765295.9
3119781
3/20/2015
9/16/2020
3/20/2035
Granted
COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE
PCT: Patent Cooperation Treaty
United States
15/126,588
11,001,581
9/16/2016
5/11/2021
3/20/2035
Granted
COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE
DIV: Divisional
United States
17/195,149
3/8/2021
Pending
Direct Link:
https://jhu.technologypublisher.com/technology/47101
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities,
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For Information, Contact:
Jeanine Pennington
jpennin5@jhmi.edu
410-614-0300
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