Detection of PAR for a Diagnosis in the CSF of Parkinson’s Disease (PD) Patients

Case ID:
C14766

Unmet Need

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by a gradual loss of all motor function. Currently, no diagnostic test exists for PD. Nevertheless, the early diagnosis of PD is critical for successful disease management as pharmacological treatments like levodopa are most effective when administered at the earliest stages of PD.


Technology Overview

Hopkins researchers have developed an assay for the detection of poly(ADP-ribose) or PAR that may effectively diagnose Parkinson’s disease. A three-year long study involving over one hundred individuals found that PAR concentration was a significant predictor of disease status.


Stage of Development

Researchers intend to validate these findings with follow up studies and additional testing in new cohorts of patients.


Publications

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease (science.org)

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
DETECTION OF PAR IN THE CSF PATIENTS WITH PARKINSON’S DISEASE DIV: Divisional United States 18/049,773   10/26/2022     Pending
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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