Unmet Need
Monoclonal Antibodies (mAB) serve an important role in cellular research and therapeutic applications. They are utilized to better understand various systems such as biochemical pathways, diseases, and mutations in the structures of invertebrates. There is a need to develop antibodies that specifically target areas within the biological landscape to further explain protein functionality, cell- regulation, and overall cellular processes (Kaur, 2020).
Technology Overview
Inventors at Johns Hopkins have developed a way to detect and characterize the components of SUMOylation using a Mouse Monoclonal Antibody. This antibody aids in a novel understanding of how SUMO-1 and SUMO 2/3 contribute to cell regulation during mitosis.
Publication
Zhang, X. D., Goeres, J., Zhang, H., Yen, T. J., Porter, A. C., & Matunis, M. J. (2008). SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. Molecular cell, 29(6), 729–741. https://doi.org/10.1016/j.molcel.2008.01.013
