Unmet Need
Monoclonal Antibodies (mAB) serve an important role in both research and medical applications to better understand components of biochemical pathways and the development of chronic diseases (Tabrizi et al, 2006[SN1] ). There is a global need for the advancement of antibodies to help target and fully understand the various, complex, molecular, and biological systems of living organisms (Kaur, 2020).
Technology Overview
Inventors at Johns Hopkins have discovered an antibody that will increase the understanding of nutrient regulation of signaling, transcription, and cellular physiology by O-GlcNAcylation. With further usage, these antibodies will also help aid in the study and research of chronic diseases.
Publication
Hardivillé, S., & Hart, G. W. (2014). Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation. Cell metabolism, 20(2), 208–213. https://doi.org/10.1016/j.cmet.2014.07.014
Zachara, N. E., Vosseller, K., & Hart, G. W. (2011). Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Current protocols in molecular biology, Chapter 17, Unit–17.6. https://doi.org/10.1002/0471142727.mb1706s95
Hart, G. W., Slawson, C., Ramirez-Correa, G., & Lagerlof, O. (2011). Cross-talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease. Annual review of biochemistry, 80, 825–858. https://doi.org/10.1146/annurev-biochem-060608-102511
