N-Substituted Hydroxylamine Derivatives with Carbon-Based Leaving Groups as Physiologically Useful Nitroxyl (HNO) Donors

Case ID:
C11700

Technology Overview

The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.


Publication

Development of N-Substituted Hydroxylamines as Efficient Nitroxyl (HNO) Donors | Journal of the American Chemical Society (acs.org)

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
N-Substituted Hydroxylamine Derivatives with Carbon-Based Leaving Groups as Physiologically Useful Nitroxyl (HNO) Donors PCT: Patent Cooperation Treaty European Patent Office 12781538.9 2776402 10/16/2012 7/26/2017 10/16/2032 Granted
N-Substituted Hydroxylamine Derivatives with Carbon-Based Leaving Groups as Physiologically Useful Nitroxyl (HNO) Donors PCT: Patent Cooperation Treaty United Kingdom 12781538.9 2776402 10/16/2012 7/26/2017 10/16/2032 Granted
N-Substituted Hydroxylamine Derivatives with Carbon-Based Leaving Groups as Physiologically Useful Nitroxyl (HNO) Donors PCT: Patent Cooperation Treaty United States 14/352,399 9,181,213 4/17/2014 11/10/2015 10/16/2032 Granted
N-Substituted Hydroxylamine Derivatives with Carbon-Based Leaving Groups as Physiologically Useful Nitroxyl (HNO) Donors DIV: Divisional United States 14/927,039 9,499,511 10/29/2015 11/22/2016 10/16/2032 Granted
N-Substituted Hydroxylamine Derivatives with Carbon-Based Leaving Groups as Physiologically Useful Nitroxyl (HNO) Donors DIV: Divisional United States 15/290,872 9,862,699 10/11/2016 1/9/2018 10/16/2032 Granted
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For Information, Contact:
Mohit Ganguly
mgangul1@jh.edu
410-614-0300
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