N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors

Case ID:

C10220

Technology Overview

The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors	ORD: Ordinary Utility	United States	12/239,705	8,227,639	9/26/2008	7/24/2012	8/1/2030	Granted
N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors	CON: Continuation	United States	13/531,364	8,674,132	6/22/2012	3/18/2014	9/26/2028	Granted
N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors	CON: Continuation	United States	14/204,636	9,115,064	3/11/2014	8/25/2015	9/26/2028	Granted
N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors	CON: Continuation	United States	14/815,917	9,617,208	7/31/2015	4/11/2017	9/26/2028	Granted

Direct Link:

https://jhu.technologypublisher.com/technology/50277

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities,

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For Information, Contact:

Mohit Ganguly

mgangul1@jh.edu

410-614-0300

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