N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors

Case ID:
C10220

Technology Overview


The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors ORD: Ordinary Utility United States 12/239,705 8,227,639 9/26/2008 7/24/2012 8/1/2030 Granted
N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors CON: Continuation United States 13/531,364 8,674,132 6/22/2012 3/18/2014 9/26/2028 Granted
N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors CON: Continuation United States 14/204,636 9,115,064 3/11/2014 8/25/2015 9/26/2028 Granted
N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors CON: Continuation United States 14/815,917 9,617,208 7/31/2015 4/11/2017 9/26/2028 Granted
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For Information, Contact:
Mohit Ganguly
mgangul1@jh.edu
410-614-0300
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