Bis-Acylated Hydroxylamine Derivatives as Physiologically Useful HNO Donors

Case ID:
C10811

Technology Overview


The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.


Publication


Optimization of HNO production from N,O-bis-acylated hydroxylamine derivatives - PubMed (nih.gov)

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Bis-Acylated Hydroxylamine Derivatives PCT: Patent Cooperation Treaty United States 12/962,544 9,018,411 12/7/2010 4/28/2015 12/7/2030 Granted
Bis-Acylated Hydroxylamine Derivatives CON: Continuation United States 14/667,622 9,458,127 3/24/2015 10/4/2016 12/7/2030 Granted
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For Information, Contact:
Mohit Ganguly
mgangul1@jh.edu
410-614-0300
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