Value Proposition
Technology Description
Researchers at Johns Hopkins have developed a peptide-based platform technology using supramolecular immunofibers (IFs) for non-chromatographic antibody purification. The platform employs co-assembly of filler and ligand molecules. In aqueous solutions, the filler and ligand molecules can spontaneously co-assemble into IFs under physiological conditions and then capture and precipitate monoclonal antibodies (mAbs).
Unmet Need
Antibody precipitation using protein A chromatography is one of the major downstream bottlenecks due to resin capacity limitation and high production cost. Affinity precipitation has been increasingly explored as a promising alternative to purify mAbs. However, high salt concentration is known to increase the risks of protein instability and non-specific precipitation of impurities present in the solution. Therefore, there is a need for an alternative mAb purification process of with high throughput, ease of handling, and reduced cost.
Stage of Development
Data Availability
Data available upon request.