VR-Expressing Cells against Multiple Cytokines and Uses Thereof

Case ID:
C17740

Unmet Need

·        Recent technological breakthroughs have highlighted the therapeutic potential of immunotherapy (e.g., CAR-T cells) and have focused attention and efforts on developing safe and effective immunotherapy modalities.

·        Despite advances in the field, there remain several challenges to both efficacy and safety of CAR-T and other immunotherapies.

·        CAR-T cells have demonstrated efficacy in treating hematological tumors.

·        Additional complexities and barriers exist in delivery of CAR-T cells to solid tumors.

·        Therefore, there is a strong need to develop more safe and effective CAR-T-based immunotherapies for the treatment of cancer, particularly solid tumors.


Value Proposition

·        Allows for enhanced trafficking of adoptively transferred CAR-T cells to solid tumor sites, improving infiltration of the tumor microenvironment.

·        May increase broad efficacy of CAR-T-based immunotherapy for both malignant and non-malignant disease indications.

 

Technology Description

·        Researchers at Johns Hopkins have developed a method for improved targeting of CAR-T-based immunotherapy for the treatment of cancer and other disease.

·        This approach allows for better regulation of migration of adoptively transferred cells to sites outside the bloodstream.

·        This approach has demonstrated potential to enhance immune cells’ immunosurveillance and migration towards solid tumors, which are otherwise difficult to target.


Stage of Development

·        2D and 3D in vitro work is complete. Currently being studied in in vivo mouse models.


Publications

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10760159/

https://sciencecast.org/casts/cd0ybihepso7/edit

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
VELOCITY RECEPTOR EXPRESSING IMMUNE CELLS AND USES THEREOF PCT: Patent Cooperation Treaty PCT PCT/US2024/032767   6/6/2024     Pending
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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