Unmet Need
· One third of diagnoses for surgical resection of pancreatic cysts are incorrect, leading to unnecessary surgery, medical risk, and high costs (Hammel, 2002). The current standard of care for determining pancreatic cyst type is based solely on symptom progression and imaging criteria, and histopathological analysis is only available following surgical resection. Thus, there is a strong need for developing improved assays for more accurate determination of pancreatic cyst type to inform surgical decisions and reduce unnecessary medical risks.
Value Proposition
· Determination of unique genetic signature that distinguishes benign and malignant pancreatic cyst types
· Validated genetic screen can reduce misidentification of cyst type compared to standard diagnostic techniques
· Ability to determine pancreatic cyst type from cyst fluid, mitigating the need for surgery
Technology Description
· Researchers at Johns Hopkins have developed a set of genetic tests to differentially identify the type of pancreatic cyst without surgical resection. Various genes are tested for mutations, loss of heterozygosity, and/or aneuploidy. The pattern of these alterations can elucidate the type of pancreatic cyst. Data demonstrates these diagnoses can be performed on cyst fluid, which can be obtained without surgery.
Stage of Development
Pre-Clinical
Data Availability
· Data available upon request.
Publications
Wu J, et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21188-93. doi: 10.1073/pnas.1118046108. Epub 2011 Dec 8. PMID: 22158988; PMCID: PMC3248495.
Springer S, et al. A combination of molecular markers and clinical features improve the classification of pancreatic cysts. Gastroenterology. 2015 Nov;149(6):1501-10. doi: 10.1053/j.gastro.2015.07.041. Epub 2015 Aug 4. PMID: 26253305; PMCID: PMC4782782.
| Title |
App Type |
Country |
Serial No. |
Patent No. |
File Date |
Issued Date |
Expire Date |
Patent Status |
| Identification of RNF43 Mutations in Pancreatic Cysts |
PCT: Patent Cooperation Treaty |
Australia |
2012339835 |
2012339835 |
11/12/2012 |
5/12/2016 |
11/12/2032 |
Granted |
| Identification of RNF43 Mutations in Pancreatic Cysts |
PCT: Patent Cooperation Treaty |
Japan |
2014-542363 |
5947392 |
11/12/2012 |
6/10/2016 |
11/12/2032 |
Granted |
| Identification of RNF43 Mutations in Pancreatic Cysts |
DIV: Divisional |
Japan |
2016-110734 |
|
11/12/2012 |
|
|
Pending |
| Identification of RNF43 Mutations in Pancreatic Cysts |
PCT: Patent Cooperation Treaty |
France |
12849091.9 |
2780473 |
11/12/2012 |
7/19/2017 |
11/12/2032 |
Granted |
| Identification of RNF43 Mutations in Pancreatic Cysts |
PCT: Patent Cooperation Treaty |
Germany |
60 2012 034 863.1 |
2780473 |
11/12/2012 |
7/19/2017 |
11/12/2032 |
Granted |
| Identification of RNF43 Mutations in Pancreatic Cysts |
PCT: Patent Cooperation Treaty |
United Kingdom |
12849091.9 |
2780473 |
11/12/2012 |
7/19/2017 |
11/12/2032 |
Granted |
| Identification of RNF43 Mutations in Pancreatic Cysts |
PCT: Patent Cooperation Treaty |
European Patent Office |
12849091.9 |
2780473 |
11/12/2012 |
7/19/2017 |
11/12/2032 |
Granted |
| Identification of RNF43 Mutations in Pancreatic Cysts |
PCT: Patent Cooperation Treaty |
United States |
14/359,149 |
9,637,796 |
5/19/2014 |
5/2/2017 |
11/12/2032 |
Granted |
