Marketing Summary
Technology Description
· Researchers at Johns Hopkins have advanced wearable microneedle biosensor technology by using a subcutaneous magnetic implant to hold the sensor in place.
· This allows for continuous detection of molecules in vivo and in real time via affinity interactions with aptamers present in the sensing array.
Unmet Need
· Wearable, microneedle biosensor patches can be used for real-time molecular monitoring in a variety of diseases (e.g., glucose monitoring in diabetes).
· However, current platforms have issues with long-term stability of patch placement on the skin, particularly the skin of rodents, which limits their reliability for pharmacological studies during drug development efforts.
· Therefore, there is a strong need to develop wearable biosensors with improved skin adherence to improve the reliability of continuous molecular monitoring in preclinical animal models and in clinical testing.
Value Proposition
· Improved long-term biosensors stability and longevity.
· More reliable and replicable real-time measurement of in vivo analytes.
· Potential applications for preclinical and clinical research, as well as in patient monitoring.
Stage of Development
· Preclinical studies in rodent models
Publications
Maria Reynoso, An-Yi Chang, Yao Wu, Raygan Murray, Smrithi Suresh, Yuma Dugas, Joseph Wang, Netzahualcóyotl Arroyo-Currás, 3D-printed, aptamer-based microneedle sensor arrays using magnetic placement on live rats for pharmacokinetic measurements in interstitial fluid, Biosensors and Bioelectronics, Volume 244, 2024, 11580.
