Value Proposition
· Identifies targets for modulation of tanycyte-derived neurogenesis.
· Demonstrates efficacy of small molecule induction of tanycyte-derived neurogenesis.
· Combines viral constructs and small molecules to generate specific subtypes of tanycyte-derived neurons.
· Applicable to a broad range of hypothalamic processes.
Technology Description
Researchers at Johns Hopkins have identified a family of transcription factors and subsequent downstream signaling that repress hypothalamic tanycyte proliferation and neurogenesis. By targeting these transcription factors and their downstream targets via viral constructs and small molecules, this technology can be used to modulate a broad range of hypothalamic physiological processes, including dietary and sleep signals.
Unmet Need
Recent studies in the retina have demonstrated negative regulation of neurogenesis by the NF1 family of transcription factors. While tanycytes have been shown to undergo neurogenesis in the newborn and postnatal hypothalamus, no studies have explored the gene regulatory networks that regulate this phenomena. Understanding these networks would provide insight into the functions of tanycyte-derived neurons and identify potential therapeutic targets for modulation of hypothalamic neural circuitry. Therefore, there is a strong need for the identification of regulators of tanycyte-derived neurogenesis.
Stage of Development
· Proof of concept studies have been performed.
Data Availability
· Data available upon request.
Publications
· Yoo et al. Control of neurogenic competence in mammalian hypothalamic tanycytes. Science Advances (2021).
