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#C17480 Organo-phosphate Modified Metal Organic Frameworks and  Applications

Inventors: Michael Tsapatsis, Efrosini Kokkoli, Danyu Wang

Unmet Need

There is a continuously growing need for new and better asymmetric catalysts, as is evidenced by the fact that the 2021 Nobel Prize in Chemistry went to two scientists for development of asymmetric organocatalysis (see Nobel Prize). Currently, most synthetic catalysis is carried out via metals, enzymes, or organocatalysts. However, many of these catalysts suffer from poor separation, recovery, and recycling after use (see Jones). Additionally, they can have limited surface area for substrate interaction. Metal-organic frameworks have the potential to overcome these limitations because their porosity creates a large surface area and allows rapid diffusion of substrate molecules, and their crystalline structure enables characterization and separation from reactions (see Yoon). Metal-organic frameworks can also be post-synthetically modified to introduce additional functionalities (see Cohen). A remaining limitation for many metal-organic frameworks is their instability over time, as they tend to degrade during reaction or regeneration (see Jasuja). Increasing the stability of metal-organic frameworks through synthesis or post-synthetic modification could create longer-lasting, high surface area, asymmetric catalysts. Therefore, there is a need for creation of metal-organic frameworks that can act as asymmetric catalysts while maintaining structure and function through several rounds of catalysis.

Technology Overview

Researchers at Johns Hopkins have developed a metal-organic framework that is post-synthetically modified and used as an asymmetric heterogenous catalyst for Michael additions and Diels-Alder reactions. The developed framework also displays enhanced stability over time.

Stage of Development

Successful asymmetric catalysis has been demonstrated.

Publication

N/A