Polymeric Nanoparticle Compositions for Encapsulation and Sustained Release of Neuromodulators

JHU Ref #: C16591

Value Proposition

·      Protein delivery system with tunable, sustained release profile, high payload capacity, and bioactivity retention

·      Neurotoxin release profile of at least 120 days

·      Scalable and translational manufacturing process

Unmet Need

·      Neurotoxins are widely used in the aesthetic and therapeutic space. Among the 16 million minimally invasive plastic surgery procedures performed in 2018, injection of Botulinum Toxin Type A (Botox) accounted for over 50% (American Society of Plastic Surgeons) These substances are typically administered to patients via injection. Neuromodulators work by paralyzing muscle bodies and subsequently provide relief for migraine and, more commonly, are used to reduce signs of aging for facial aesthetics. However, the products currently on the market suffer from fast clearance from the inject site with only a 14-day maximally effective release period. This requires that the patient undergoes follow-up visits at least every 3 months. Thus, there is a need for a delivery mechanism that facilitates sustained release of the neurotoxin.

Technology Overview

·      Inventors at Johns Hopkins have a developed a poly electrolyte nanocomplex (PNC) capable of encapsulating one or more neuromodulators. Here, they have optimized the nanoparticle to form a neuromodulator-polyanion nanocomplex that maintains the protein package’s bioactivity and release rate, allowing for high encapsulation efficiency and larger loading capacity. This platform allows for long-term release of the neuromodulator, with a release duration ranging from 1 to 6 months, which expands the total duration of effect to between 6 and 9 months. Furthermore, the production process for these nanoparticles have been optimized to allow for scalable production and manufacturing.

Stage of Development

·      The inventors have developed a working prototype and currently undergoing animal testing.

Data Availability

·      N/A

Publication

·      N/A