Nanofiber Hydrogel Composite Gel to Prevent Scarring and Adhesion of Peripheral Nerves

Case ID:
C17294

JHU Ref #: [C17294]

 

Value Proposition:

·       Application of composite hydrogel to mechanically irritated nerves can reduce perineural adhesions and scar formation.

·       Improves patient outcomes following peripheral nerve surgery.

 

Technology Description

·       Researchers at Johns Hopkins have developed a nanofiber-hydrogel composite (NHC) material platform.

·        This injectable hydrogel formulation mimics the microarchitecture and mechanical properties of soft tissue extracellular matrix.

·       NHC has significant surgical and regenerative medicine applications.

Unmet Need

·       Peripheral nerve surgeries are becoming increasingly common with age-related nerve disease and traumatic injuries.

·       There is significant innovation in surgical technique and medical devices to address these diseases.

·       However, nearly all require mechanical disruption of the peripheral nerve, which is prone to adhesion and potential scar-inducing injury.

·       Therefore, there is a clear need for a solution that prevents these occurrences, optimizing the long-term success of peripheral nerve surgical interventions.


Stage of Development

In vivo studies have been performed in rodent models of peripheral nerve injury.

 

Publication

N/A

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
NANOFIBER-HYDROGEL COMPOSITES AND METHODS FOR INHIBITING ADHESION FORMATION PCT: Patent Cooperation Treaty PCT PCT/US2023/075657   9/30/2023     Pending
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For Information, Contact:
Lisa Schwier
lschwie2@jhu.edu
410-614-0300
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