A novel flexible implantable electroceutical device for recording and stimulating gastric activity

Case ID:
C17629

Unmet Need

·        Gastroparesis and functional dyspepsia (FD) are debilitating stomach disorders that together affect more than 10% of the world population.

·        Current approaches to treatment focus on symptom management, with pharmacological treatment being first-line; treatment efficacy is limited.

·        Gastric electric stimulation devices are a non-drug treatment option for those with severe and/or refractory disease, but have unproven clinical efficacy.

·        Therefore, there is a strong need for safe, clinically effective electroceutical devices to treat gastroparesis and FD.

Value Proposition

·        Gastric electrical stimulation (GES) device capable of both continuously recording gastric motility and administering GES.

·        Closed-loop system that incorporates feedback from motility monitoring to deliver precise stimulation at the physiologically-appropriate time.

·        Able to selectively stimulate enteric neurons in sync with natural gastrointestinal slow wave patterns resulting in relaxation of the pyloric sphincter muscles to promote gastric emptying.

Technology Description

·        Researchers at Johns Hopkins have developed a chronically-implantable electroceutical device for treatment of gastroparesis and Functional Dyspepsia (FD).

·        The device is implanted in the stomach and is capable of both monitoring gastric activity and administering gastric electrical stimulation (GES) to alleviate symptoms.

Stage of Development

·        Validated prototype in animal models of gastroparesis/FD.

Publication

N/A

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
DEVICES AND RELATED ASPECTS FOR RECORDING AND STIMULATING GASTRIC ACTIVITY PCT: Patent Cooperation Treaty PCT PCT/US2023/080192   11/21/2023     Pending
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For Information, Contact:
Lisa Schwier
lschwie2@jhu.edu
410-614-0300
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