Value Proposition
· Non-invasive: MRI-based computational modeling provides guidance for catheter-based ablation or LV electrode placement in the treatment of hear disease.
· Personalized: Predicts location of optimal ablation or LV electrode placement for each patient.
Unmet Need
· Ventricular tachycardia (VT) in the setting of myocardial infarction is associated with increased risk of sudden cardiac death.
o Catheter-based ablation, which has become a safe and effective first-line therapy for other types of cardiac arrythmias is associated with low levels of success in eliminating infarct-related VT.
o Low response rates are due to numerous limitations to current voltage and pace mapping techniques that often miss critical sites for ablation.
· Similarly, cardiac resynchronization therapy (CRT) has been shown to reduce morbidity and mortality in patients, yet 30% of patients fail to respond to CRT.
o The location of the left ventricular (LV) pacing lead plays an important role in CRT efficacy, but determining this location in a patient-specific manner is not currently possible.
· Therefore, there is a need for better identification of optimal targets of ablation or CRT in order to achieve better patient outcomes.
Technology Description
· Researchers at Johns Hopkins have developed a non-invasive in-silico methodology for MRI-based guidance of infarct-related VT ablation and placement of the LV electrode for CRT.
Stage of Development
· Proof of concept
Publication
[1] Prakosa, A. et al. Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia. Nature Biomedical Engineering 2, 732-740 (2018). DOI: https://doi.org/10.1038/s41551-018-0282-2
Title |
App Type |
Country |
Serial No. |
Patent No. |
File Date |
Issued Date |
Expire Date |
Patent Status |
Patient-specific simulation guidance of infarct-related ventricular ablation and cardiac resynchronization therapy |
PCT: Patent Cooperation Treaty |
European Patent Office |
12745321.5 |
2672889 |
2/10/2012 |
4/7/2021 |
2/10/2032 |
Granted |
Patient-specific simulation guidance of infarct-related ventricular ablation and cardiac resynchronization therapy |
PCT: Patent Cooperation Treaty |
Australia |
2012214163 |
2012214163 |
2/10/2012 |
7/21/2016 |
2/10/2032 |
Granted |
Patient-specific simulation guidance of infarct-related ventricular ablation and cardiac resynchronization therapy |
PCT: Patent Cooperation Treaty |
Israel |
227906 |
227906 |
2/10/2012 |
3/30/2017 |
2/10/2032 |
Granted |
SYSTEM AND METHOD FOR PLANNING A PATIENT SPECIFIC CARDIAC PROCEDURE |
PCT: Patent Cooperation Treaty |
Japan |
2013-553621 |
6203641 |
2/10/2012 |
9/8/2017 |
2/10/2032 |
Granted |
Patient-specific simulation guidance of infarct-related ventricular ablation and cardiac resynchronization therapy |
DIV: Divisional |
Australia |
2016204898 |
2016204898 |
2/10/2012 |
4/19/2018 |
2/10/2032 |
Granted |
Patient-specific simulation guidance of infarct-related ventricular ablation and cardiac resynchronization therapy |
PCT: Patent Cooperation Treaty |
France |
12745321.5 |
2672889 |
2/10/2012 |
4/7/2021 |
2/10/2032 |
Granted |
Patient-specific simulation guidance of infarct-related ventricular ablation and cardiac resynchronization therapy |
PCT: Patent Cooperation Treaty |
Germany |
12745321.5 |
2672889 |
2/10/2012 |
4/7/2021 |
2/10/2032 |
Granted |
Patient-specific simulation guidance of infarct-related ventricular ablation and cardiac resynchronization therapy |
PCT: Patent Cooperation Treaty |
United Kingdom |
12745321.5 |
2672889 |
2/10/2012 |
4/7/2021 |
2/10/2032 |
Granted |
Patient-specific simulation guidance of infarct-related ventricular ablation and cardiac resynchronization therapy |
PCT: Patent Cooperation Treaty |
United States |
13/984,741 |
10,765,336 |
11/20/2013 |
9/8/2020 |
9/19/2032 |
Granted |
SYSTEM AND METHOD FOR PLANNING A PATIENT-SPECIFIC CARDIAC PROCEDURE |
CON: Continuation |
United States |
16/995,513 |
12,076,150 |
8/17/2020 |
9/3/2024 |
9/19/2032 |
Granted |