Nanofiber Nerve Cuff to Inhibit Neuroma Formation
JHU Ref #: [C17593]
Value Proposition:
· This device can be used to cap the end of a severed nerve to prevent unwanted nerve growth through a combination of physical and biochemical mechanisms.
· This device is more effective than existing nerve caps and cuffs, due to the inclusion of bioactive agents that biochemically influence nerve growth.
Technology Description
· Researchers at Johns Hopkins have developed a nanofiber nerve cuff device that can be used to inhibit neuroma formation.
· This technology uses a nanofiber matrix to cover the severed end of a nerve at the site of injury.
· This semi-permeable matrix allows for nutrient exchange, fluid transport, and immunomodulation.
· Bioactive fillers and embedded bioactive materials slowly release small molecules that inhibit axon regeneration.
· This device can prevent painful neuroma growth in patients with peripheral nerve injuries, with a particular focus on amputee patients.
Unmet Need
· Painful neuromas can develop following peripheral nerve injury, particularly among amputees.
· There are ~2 million patients in the United States who have undergone amputation surgery, with ~185k procedures each year.
· Neuromas are commonly treated with surgical resection, which is invasive and can lead to complications (e.g. further nerve damage, scarring).
· Therefore, there is a strong need to develop a less invasive solution that address the formation of neuromas.
Stage of Development
· Physical prototype with pre-clinical in vivo data from small animal models.
· Looking for corporate partnerships
Publication
N/A
