Value Proposition
· High-throughput
· Assess genetic variants with simultaneous spatial analysis
· Interrogate over 100 variants in a single assay
Unmet Need
· Next generation sequencing has led to an ever-proliferating dearth of genetic information. More recent progress in nucleoside tissue analysis has birthed the field of spatial transcriptomics. While current methods allow for in-situ interrogation of spatial expression patterns with both sequencing-based and imagining based techniques, these assays are limited in their scope and accuracy at scale (Wang, 2023). Therefore, there is a need for development of technologies for spatial transcriptomics at larger and higher throughput scale.
Technology Description
· Researchers at Johns Hopkins have developed a transcriptomic technique to interrogate RNA transcripts in tissue sections at scale. The technique allows for the characterization of over one hundred different RNA single nucleotide variants simultaneously in tissue slices. Additionally, the technology allows for this investigation to capture data with significantly higher accuracy and predictive disease classifications than currently available detection methods.
Stage of Development
· Proof-of-concept completed.
