Nanoparticles for Topical Drug Delivery and Treatment of Hair Growth Conditions
JHU REF: [C11686]
Invention novelty: This invention is a nanoparticle for topical drug delivery targeting hair growth conditions. The particle may be an effective drug delivery tool for conditions such as hirsutism (excess hair) or alopecia (hair loss).
Value Proposition
This technology can be used as a treatment for hair loss or excessive hair growth. The drug delivery vehicle, a solid lipid nanoparticle (SLN), and offers better epidermal penetration than current state of the art topical drug delivery systems. The drug release mechanism of this SLN can be controlled by temperature, and has been optimized to work under physiological conditions. In preliminary studies the SLN was found to accumulate in hair follicles, meaning pharmaceuticals can be targeted with high specificity to these areas.
Technical Details
Johns Hopkins researchers have developed a solid lipid nanoparticle (SLN) for topical drug delivery. This particle may allow for much deeper penetration into the skin than was possible with the older SLNs. The SLN molecule encapsulates the drug of interest and diffuses into the epidermis, where it then accumulates in the hair follicle. Under normal skin temperature conditions the particle melts, releasing the drug compound in a specific, controlled area.
Looking for Partners: To develop and commercialize the technology as a topical treatment for hair loss or excessive hair growth.
Stage of Development: Pre-clinical
Data Availability: Human and animal data- SLNs containing imaging molecules were applied to tissue samples. Accumulation in hair follicles was seen.
Inventors: Jason J. Benkoski, Jennifer L. Sample, Marcia W. Patchan, Luis A. Garza, Xiomara Calderon-Colon, Julia Patrone, Joshua Wolfe, Mellisa Theodore, Amanda Nelson, Sewon Kang
Patent Status: Pending
Publication(s)/Associated Cases: US Issued Patent 10,758,630
