Partitioning of Human Mesenchymal Stem Cells based on Expression of CD201 or CD141
C17534
Unmet Need
Bone defects are common and devastating conditions that are addressed in over 2.2 million surgeries yearly. Additionally, the biomedical burden of soft tissue defects is likewise enormous, estimated to be addressed in 5.2 million surgeries yearly. Autologous stem cell therapies hold great promise for the treatment of defects in both bone and soft tissue. With clinical trials of mesenchymal stem cells (MSC)-based bone repair demonstrating suboptimal results, use of a defined progenitor cell is of paramount importance in the field. Therefore, there is a strong need to develop a method for separating defined progenitor cells for stem cell-based therapies.
Technology Overview
Researchers at Johns Hopkins have discovered a biomarker for vasculature derived mesenchymal stem cells. The researchers describe a defined biomarker that correlates to uncommitted progenitor cells. This method would allow for separation of defined progenitor cells for stem cell-based therapies.
Stage of Development
In vitro and small animal data is available.
Availability
Cells and sequencing data available upon request.
Publication
Human blood vessel walls contain a spatially defined niche for mesenchymal precursor cells with distinct differentiation potential defined by CD201 expression
M Gomez-Salazar, Y Wang, N Thottappillil, R Tower, L Chang, ...
JOURNAL OF BONE AND MINERAL RESEARCH 38, 35-35
Transcriptomic Mapping of Human Blood Vessels Defines Spatially Restricted Adventitial Progenitor Niche
N Thottappillil, Y Wang, M Gomez-Salazar, R Tower, Q Qin, I Del Rosario, ...
CIRCULATION RESEARCH 133 (12), E57-E57
Integrated transcriptomics of human blood vessels defines a spatially controlled niche for early mesenchymal progenitor cells
Y Wang, N Thottappillil, M Gomez-Salazar, RJ Tower, Q Qin, ICDR Alvia, ...
Developmental cell 59 (20), 2687-2703. e6
Abstract Tu0076: Thrombomodulin expression identifies a subset of human vascular adventitia resident progenitor cells N Thottappillil, S Onggo, MA Gomez Salazar, Y Wang, Z Li, X Xing, ... Arteriosclerosis, Thrombosis, and Vascular Biology 45 (Suppl_1), ATu0076-ATu0076
