Non-Confidential Title
· Low-volume, extended-release therapeutics for neuroprotection
JHU Ref #: C17657
Value Proposition
· High concentration, low volume, solvent-free microcrystal preparation of neuroprotective compounds.
· Facilitates direct delivery and sustained release of neuroprotective compounds to areas where low volumes are required (e.g., eye, inner ear, brain).
· Formulation demonstrates stability after lyophilization and reconstitution.
Unmet Need
· Disease treatment can require drug delivery to small-volume areas, such as the eye or inner ear.
· Small areas are unable to accommodate large volumes of injected drug; repeat injections are also required to treat locations that are inaccessible by systemic delivery (e.g., eye).
· Neuroprotective compounds are only available in higher-volume formulations. This has led to undertreatment of some medical conditions.
· Therefore, there is a strong need to develop methods for the production of high-concentration, low-volume drug formulations to improve patient outcomes and quality of life.
Technology Description
· Researchers at Johns Hopkins have developed a method for producing solvent-free microcrystals.
· These formulations can be used for high concentration, low volume injections for sustained neuroprotection in the eye and inner ear.
· This method includes a series of distillation, sterilization, and lyophilization steps.
Stage of Development
· Benchtop-scale production of microcrystal formulations.
Publication
N/A
