Value Proposition:
· High-throughput screening of loci for exogenous gene insertion
· Quantifies expression level of exogenous genes in cell type of interest
Unmet Need
· Exogenous or synthetic genes that are inserted into the genome serve various purposes, depending on the context and goals of the genetic modification. This includes therapeutic, research, agricultural or industrial purposes. The location of the genomic insertion of the construct, known as the harbor, is imperative for the function of the exogenous gene. However, there is a need to systematically characterize various loci for construct insertion.
Technology Description
· Researchers at Johns Hopkins have developed a method for high-throughput screening of genomic sites for insertion of exogenous constructs. This approach allows researchers to determine suitable harbors for expressing transgenes in target cells.
Stage of Development
· Proof of concept completed. Looking for partners to develop and commercialize technology.
Data Availability
Data available upon request.
