Molecule for Promoting Wound Healing

Value Proposition

·      Flexibility to be combined with various types of topical medications or delivery mechanisms

·      Easily manufactured key ingredients

Unmet Need

·      Chronic wounds persist for long periods of time without adequate healing response. They may take various forms, such as vascular ulcers, diabetic foot ulcers, or sacral pressure ulcers. They are prevalent around the world, with significant burden in specific populations, such as those residing in long-term care facilities or those with diabetes. Some estimate that they impact 5% of the adult population and account for 10% of healthcare expenditures. (Wang, 2023). There exists a strong need for developing a method to enhance and promote healing of chronic wounds.  

Technology Description

·      Current methods for biologically based treatments for chronic wounds are limited and face challenges when applied to bacterially colonized wound environments. Researchers at Johns Hopkins have developed a method to promote wound healing that is synergistic with bacteria found in chronic wounds. Research demonstrates that this molecule is compatible with topical application.

Stage of Development

·      Benchtop proof of concept has been demonstrated.

·      Current efforts focus on elucidating most key steps of skin regrowth pathway and appropriate molecule delivery and formulation

Data Availability

·      Data available upon request.

Publication

1. Wang G, Sweren E, Andrews W, Li Y, Chen J, Xue Y, Wier E, Alphonse MP, Luo L, Miao Y, Chen R, Zeng D, Lee S, Li A, Dare E, Kim D, Archer NK, Reddy SK, Resar L, Hu Z, Grice EA, Kane MA, Garza LA. Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism. Sci Adv. 2023 Jan 4;9(1):eabo7555. doi: 10.1126/sciadv.abo7555. Epub 2023 Jan 4. PMID: 36598999; PMCID: PMC9812389.
2. Patent Application: WO 2025/147348