Search Results - vinayak+khodade

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Alkylsulfenyl Thiocarbonates as Precursors to Hydropersulfides

Unmet Need:According to a survey by the CDC, nearly 50% of Americans age 20 and up have some form of cardiovascular disease (see AHA). The management of cardiovascular diseases depends on the specific indication, and standard therapies include one or multiple of the following types of medications: blood thinners, ACE inhibitors, beta-blockers, calcium...

Published: 5/10/2024 | Inventor(s): John Toscano, Vinayak Khodade, Sahil Aggarwal, Nazareno Paolocci, Blaze Pharoah, Gizem Keceli, Kelsey Zhang

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Oncology

Alkylamine-Substituted Perthiocarbamates as Dual Precursors to Hydropersulfide and Carbonyl Sulfide

Unmet NeedCell signaling through hydrogen sulfide (H2S) derivatives is physiologically important and is thought to occur primarily through the generation of hydropersulfides (RSSH) via sulfation of cysteine residues (RSH) on proteins. Moreover, generation of carbonyl sulfide (COS) is known to form H2S through the enzymatic activity of Carbonic Anhydrase...

Published: 5/10/2024 | Inventor(s): John Toscano, Vinayak Khodade

Keywords(s):

Category(s): Technology Classifications > Engineering Tech, Technology Classifications > Research Tools

S-Substituted Thioisothioureas as New Physiologically Useful Hydropersulfide Donors

Unmet NeedHydrogen sulfide (H2S) has long been studied as an endogenous signaling molecule responsible for a variety of bodily functions including inhibition of inflammation, inhibition of oxidative stress and regulation of calcium and pH levels in brain cells (anti-Parkinson’s Disease). In addition, liver and ovarian cancer cells have been shown to...

Published: 5/9/2024 | Inventor(s): John Toscano, Vinayak Khodade

Keywords(s):

Category(s): Technology Classifications > Engineering Tech > Materials, Technology Classifications > Therapeutic Modalities > Small Molecules