Search Results - clinical+and+disease+specializations+%3e+oncology

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CRISPR/Cas9 and Tumor-Specific Guide RNAs as a Specific and Selective Cancer Cell Killing Biologic Platform

Value Proposition: Specific targeting of mutations can treat any cancer with the specified mutations. Selective cell killing spares healthy tissue while eliminating cancer cells. Pan-cancer efficacy as guide RNAs are developed to target a wide breadth of cancer-specific mutations. Integration into host cells prevents healthy cells from transforming...

Published: 5/14/2024 | Inventor(s): James Eshleman, Selina Shiqing Teh, Kirsten Bowland, Nicholas Roberts

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Pancreatic Ductal Adenocarcinoma, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Research Tools > Nucleic Acids

Adoptive Proinflammatory Myeloid Cell Therapy for Cancer

Unmet Need: Prostate cancer is one of the most commonly diagnosed cancers in the male population; roughly one out of ten men will be diagnosed at some point in their lives. Despite extending survival, androgen depravation therapy invariably leads to the development of lethal castration resistant prostate cancer. Similarly, pancreatic ductal carcinoma...

Published: 5/17/2024 | Inventor(s): Alan Friedman

Keywords(s): Biologics, Cancers, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics, Whole cell

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Oncology

Treatment of fibrosis-associated pathologies through downstream TGF-β pathway inhibition

Value PropositionInhibits downstream signaling pathway of TGF-β signaling, reducing pleiotropic and off-target effects.Selectively targets tissue specific calpains, increasing efficacy as compared to current TGF-β signaling pathway inhibitory methods.Applicable to several disease models with specific focus on epithelial-to-mesenchymal transition pathologies....

Published: 5/9/2024 | Inventor(s): David Kim, Harry Dietz

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Fibrosis Disorders, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Alkylsulfenyl Thiocarbonates as Precursors to Hydropersulfides

Unmet Need:According to a survey by the CDC, nearly 50% of Americans age 20 and up have some form of cardiovascular disease (see AHA). The management of cardiovascular diseases depends on the specific indication, and standard therapies include one or multiple of the following types of medications: blood thinners, ACE inhibitors, beta-blockers, calcium...

Published: 5/10/2024 | Inventor(s): John Toscano, Vinayak Khodade, Sahil Aggarwal, Nazareno Paolocci, Blaze Pharoah, Gizem Keceli, Kelsey Zhang

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Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Oncology

Phenotypic Microarray for Diagnosis of Cancer

Invention novelty: High Throughput Screening of pancreatic cancer cells by developing a phenotypic microarray Value Proposition: The market for cancer diagnostics is ever-expanding as the focus of global research on cancer reached its peak in the past five years. The use of microarrays as an ideal diagnostic tool for cancer detection is being realized...

Published: 5/9/2024 | Inventor(s): Denis Wirtz, Pei-Hsun Wu, Shyam Khatau, Wei-Chiang Chen, Zev Binder, Jude Phillip, Yiider Tseng

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Pharmakodynamic Biomarker, Prognostic Biomarker, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Assays

Antitumor drug interrupting glucose metabolism as a therapeutic strategy for cancer

Value Proposition:· Drug reduces tumor burden by interrupting cancer cells’ reliance on glucose metabolism.· Tolerated by healthy, normal cells.· Potential for combination therapy with other modalities (chemotherapy, radiation, immunotherapy, etc.) Technology Description· Researchers at Johns Hopkins have developed a drug to reduce...

Published: 5/10/2024 | Inventor(s): Ling He

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Detection of Cancer in Body Fluids Using Cell Enrichment and Flow Cytometry

Unmet NeedEarly detection of cancer is critical for diagnosis, informing treatment, and improving prognostic outcomes. Solid biopsies can be difficult to obtain and provide limited information on tumor composition. In recent years, liquid biopsies have allowed for non-invasive testing of circulating tumor-derived components, such as tumor cells or nucleic...

Published: 5/10/2024 | Inventor(s): Jonathan Dudley, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Precision Medicine Tools, Technology Classifications > Diagnostics > Companion Diagnostics, Clinical and Disease Specializations > Oncology

Chemokine-derived Peptides that Induce Immunogenic Cancer Cell Death

Value PropositionHigh cancer cell specificity by cell surface characteristics.High water solubility.Combination of oncolytic and anti-angiogenic properties.Unmet NeedThere currently are no peptides reported to have both oncolytic and anti-angiogenic activities. Additionally, drug development requires solubility in water; however, the reported oncolytic...

Published: 5/10/2024 | Inventor(s): Aleksander Popel, Natsuki Furukawa, Niranjan Pandey, Adam Mirando

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Peptides, Technology Classifications > Therapeutic Modalities > Peptides

Nanoparticles for Delivery of Immunoregulatory Materials to T Cells

Value Proposition:· This platform improves current methods for expansion of CD4+ T-cells, which could be used in adoptive transfer therapies.· Improves modulation, activation, and expansion of T cells over current methods used for CAR T-cell therapyTechnology Description· Researchers at Johns Hopkins have developed a nanoparticle-based...

Published: 5/10/2024 | Inventor(s): Jonathan Schneck, Ariel Isser

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Oncology, Technology Classifications > Engineering Tech, Technology Classifications > Therapeutic Modalities

Compositions of Kinetic Nanoparticles containing Nucleic Acids, Polycations, and Lipids with Defined Sizes, and Methods of Producing the Same

Value Proposition:· Scalable, efficient, and tunable nanoparticle creation technique that can deliver a variety of payloads· Polymer-lipid nanoparticles are biodegradable and are being tested for immunogenicity· Can be used for in vivo gene therapy delivery as well as in vitro cell transfection and research applications Technology...

Published: 5/10/2024 | Inventor(s): Hai-Quan Mao, Stephany Tzeng, Jordan Green, Yizong Hu, Sashank Reddy, Leonardo Cheng

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