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Phenotypic Microarray for Diagnosis of Cancer

Invention novelty: High Throughput Screening of pancreatic cancer cells by developing a phenotypic microarray Value Proposition: The market for cancer diagnostics is ever-expanding as the focus of global research on cancer reached its peak in the past five years. The use of microarrays as an ideal diagnostic tool for cancer detection is being realized...

Published: 5/9/2024 | Inventor(s): Denis Wirtz, Pei-Hsun Wu, Shyam Khatau, Wei-Chiang Chen, Zev Binder, Jude Phillip, Yiider Tseng

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Pharmakodynamic Biomarker, Prognostic Biomarker, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Assays

Diagnostic and Treatment Target for Checkpoint Inhibitor Pneumonitis

Unmet Need Checkpoint inhibitor pneumonitis (CIP) can develop as a complication of cancer immunotherapy and is the leading cause of treatment-related death. CIP incidence will continue to rise as immunotherapy treatments become more widespread. However, there are no reliable biomarkers for CIP diagnosis or prognosis. Current approaches for CIP management...

Published: 5/10/2024 | Inventor(s): Karthik Suresh, Mohammad Ghanbar, Franco D'alessio

Keywords(s):

Category(s): Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets

Machine Learning Algorithm for Delirium Prediction in the Intensive Care Unit

Unmet NeedDelirium is a potentially preventable and often reversible disorder of impaired cognition. It is common in the intensive care unit (ICU), with an overall prevalence of 32.3%. However, the prevalence is dependent on the type of patients. For example, among ventilated burn patients, the prevalence is 77%, and among mechanically ventilated patients,...

Published: 5/10/2024 | Inventor(s): Robert Stevens, Kirby Gong, Akaash Sanyal, Joanna Guo, Ryan Lu, Teya Bergamaschi, Han Kim

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Dementia, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics > Prognostic Biomarkers

CloneRetriever: An Automated Algorithm to Identify B-cell and T-cell Gene Rearrangements by Next-Generation Sequencing

Unmet NeedIn the U.S., there are an estimated 1,297,027 people living with blood cancers (leukemia, lymphoma or myeloma), with an additional 178,520 people expected to be diagnosed each year (see Leukemia & Lymphoma Society). Diagnostics tools that utilize next-generation sequencing (NGS) technologies are often performed to identify gene rearrangements...

Published: 5/10/2024 | Inventor(s): Rena Xian, Eitan Halper-Stromberg, Richard Ambinder

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Prognostic Biomarkers

Urinary Glycoproteins for the Early Detection of Aggressive Prostate Cancer

Unmet NeedAccording to the American Cancer Society, prostate cancer is one of the most commonly diagnosed cancers and is the second leading cause of cancer death in men. However, most patients with prostate cancer have the low-risk, nonaggressive form that does not require invasive intervention or treatment. The gold standard of diagnosing men with...

Published: 5/9/2024 | Inventor(s): Hui Zhang, Mingming Dong, Tung-Shing Lih

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prostate Cancer

Category(s): Technology Classifications > Diagnostics > Prognostic Biomarkers, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics

Quantitative method to identify the source of hepatitis B surface antigen

Unmet Need / Invention Novelty: Loss of hepatitis B surface antigen (HBsAg) is defined as a functional cure for chronic hepatitis B virus infection, but it is clinically challenged by the derivation of HBsAg from two sources that must be uniquely targeted: covalently closed circular DNA (cccDNA) and integrated HBV DNA (iDNA). Currently, no rapid method...

Published: 5/10/2024 | Inventor(s): Ashwin Balagopal, Chloe Thio, Tanner Grudda, Hyon Hwang

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Hepatitis B Virus, Technology Classifications > Diagnostics > Prognostic Biomarkers

BMETS Shared Decision Support Platform

Unmet NeedBone is the third most frequent site of tumor metastasis; it is estimated that 280,000 patients in the United States are living with symptomatic bone metastasis (SBM). Currently, physicians use their intuition and subjective experience with patients suffering from bone metastasis to make survival predictions that guide treatment decisions....

Published: 5/10/2024 | Inventor(s): Sara Alcorn, Jacob Fiksel, Scott Zeger, Theodore DeWeese, Thomas Smith, Todd Mcnutt, Jean Wright, Chen Hu, Lawrence Kleinberg, Christen Elledge

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics > Prognostic Biomarkers

Capture of ctDNA directly from Flowing Plasma using a dCas9 Capture System

Unmet NeedIt is estimated that, in 2020, 1,806,590 people were diagnosed with cancer and 606,520 people will die from the disease (see NCI). Nevertheless, there are a limited number of molecular diagnostic methods that are routinely deployed in clinical practice. Although the amount of ctDNA is dependent on tumor stage, size, tumor type, among other...

Published: 5/10/2024 | Inventor(s): Bradley Downs

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Novel Biomarker for Breast Cancer Detection Outcome and Treatment Sensitization to Nucleolin and CDK Inhibitors

Unmet Need: Despite widespread research efforts, breast cancer remains the second leading cause of cancer deaths in women. There is an urgent need to identify novel biomarkers and treatment strategies against aggressive forms of breast cancer to improve prognosis and therapy. Technical Details: Johns Hopkins researchers have identified a novel biomarker...

Published: 5/9/2024 | Inventor(s): Vanessa Merino, Saraswati Sukumar, Martin Pomper

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prognostic Biomarker, Prostate Cancer

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Therapeutic Modalities > Targets

Compositions and Biomarkers for Human Cancer and Methods of Use

Novel biomarkers for the detection and prognosis of several cancersJHU REF: C12506 Invention novelty: This invention has discovered high frequency mutations in the telomerase reverse transcriptase (TERT) promoter of certain cancers. Value Proposition: Early detection is usually critical for the successful treatment of cancer, therefore there is...

Published: 5/9/2024 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettegowda, Yuchen Jiao, Darell Bigner, Hai Yan, Zachary Reitman, Patrick Killela

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

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